High‐fidelity binding of transcription factors (TFs) to DNA target sites is fundamental for proper regulation of cellular processes, as well as for the maintenance of cell identity. Recognition of cognate binding motifs in the genome is attributed by and large to the DNA binding domains of TFs. As an additional mode of conferring binding specificity, noncoding RNAs (ncRNAs) have been proposed to assist associated TFs in finding their binding sites by interacting with either DNA or RNA in the vicinity of (...) their target loci. However, a well‐documented example of such a mechanism was lacking until we recently reported that a ncRNA made by Epstein‐Barr virus uses an RNA–RNA interaction with nascent transcripts generated from the viral genome to facilitate the recruitment of an interacting TF, PAX5, to viral DNA. This proof‐of‐principle finding suggests that cellular ncRNAs may likewise function in guiding interacting TFs to chromatin target sites. (shrink)

The paper argues that the common notion that there is a gap between a physical scope, namely, brain processes, and something immaterial such as private experiences is an illusion provoked by the conceptual conflicts of our understanding. In order to overcome this illusion, it is necessary to clarify the foundations and implications of the uses of key concepts in the cognitive field.

Our objective in this paper is twofold: first, we intend to address the tenability of the enactivist middle way between realism and idealism, as it is proposed in The Embodied Mind. We do so by taking the enactivist conception of bringing forth a world literally in three conceptual levels: enaction, niche construction and social construction. Based on this proposal, we claim that enactivism is compatible with the idea of an independent reality without committing to the claim that organisms have cognitive (...) access to a world composed of properties specified prior to any cognitive activity. Our second goal is to show that our literal interpretation of bringing forth a world not only sustains the legitimacy of the middle way, but it also allows us to revive the conception of evolution as natural drift—which is perhaps the least examined aspect of the original enactivist theory and is central to the understanding of cognition in an enactive way. Natural drift focuses on how structural couplings between organism and environment trigger viable pathways of maintenance and reproduction, instead of selecting the most adapted trait to a pregiven environment. Thus, although enactivists typically do not explore the consequences of their views regarding evolutionary dynamics, we show how natural drift provides a suitable starting point. (shrink)

O presente artigo apresenta alguns fatores relacionados à permanência, rompimento e retomo de mulheres agredidas à relação conjugal, bem como alguns depoimentos. Conclui-se que a conscientização das mulheres do seu papel na perpetuação desse ciclo é fundamental para que ela possa tomar-se a protagonista das mudanças na relação.

Lucia Schwarz urges a reconsideration of the implications of species egalitarianism, which is an essential element of the position in environmental ethics that Paul Taylor calls “respect for nature.” Species egalitarianism’s claim that every living thing has equal inherent worth appears to lead to counterintuitive conclusions, such as that killing a human being is no worse than killing a dandelion. Species egalitarians have generally responded by explaining that species egalitarianism is compatible with recognizing moral differences between killing different types (...) of living things, and that some killing is morally permissible. Schwarz raises doubts about whether this deflationary defensive strategy is philosophically justified, and suggests that taking seriously the supposedly repugnant implications of species egalitarianism may have a salutary effect on the overall debate. (shrink)

This paper addresses the notion of dialectics in the linguistic bodies theory. First, it presents it as a three-aspect concept, namely, the ontological aspect, the methodological aspect, and the dialectical model. Subsequently, it discusses the ontological aspect and the dialectical model and, based on the enactivist linguistic notions of concreteness and abstraction, suggests that it can be conceived as a two-fold concept: methodological and epistemological. This suggestion intends to avoid the paradox we are led to by acknowledging three ontological enactivist (...) claims and a few assumptions of the methodological approach.Keywords: Dialectics, Enactivism, Language, Epistemology, Ontology. (shrink)

Este artigo é um recorte do projeto de pesquisa “Leitura de imagens no ensino de História: um estudo sobre mudanças e permanências nas prescrições, livro didático e representações culturais”. Ele apresenta uma análise, dentre as muitas possíveis, da condição leitora na obra Cuore, escrita por Edmondo De Amicis, traduzida para o português brasileiro com o título Coração. Centenário, o livro teve sua primeira edição publicada no ano de 1886, na Itália, e tornou-se um grande sucesso editorial, principalmente por ter sido (...) adotado nas escolas. Nesta investigação, foram analisados quatro exemplares publicados na metade do século XX no Brasil, com enfoque na materialidade da obra. Buscou-se identificar as relações entre as características de apresentação do livro, identificadas nas capas, nas ilustrações e na escolha da linguagem, com a prática de leitura. Esta investigação baseia-se nas considerações de Chartier sobre o livro escolar como objeto de circulação. Outros estudos fundamentais, que tratam da análise do projeto gráfico, da função da ilustração e da leitura enquanto prática social, são aqui apresentados e discutidos, respectivamente, a partir de Collaro, Camargo e Kleiman. Como método de análise, optou-se pelo estudo bibliográfico, pela busca e análise de diálogos informais sobre a experiência leitora da obra, e por pesquisa de campo em bibliotecas e hemerotecas. Em relação aos resultados, a presente investigação permitiu concluir que: o livro Coração circulou no Brasil, sobretudo na região nordeste do Estado do Rio Grande do Sul; a padronização dos exemplares no formato bolso do livro possibilitou acessar mais facilmente os seus destinatários, inclusive pelo valor de venda, possível graças ao investimento em altas tiragens para distribuição e circulação interna na Itália e também no exterior; o projeto editorial, no decorrer do tempo, reuniu aspectos visuais que dinamizam e promovem o estímulo à leitura; a prática de leitura do livro em voz alta, usada pelos professores na escola, foi força persuasiva à leitura e contribuiu à sensibilização dos alunos aos conteúdos dos contos presentes na obra. (shrink)

What remains of moral judgment when truth itself is mistrusted, when the validity of every belief system depends on its context, when power and knowledge are inextricably entangled? Is a viable moral theory still possible in the wake of the postmodern criticism of modern philosophy? The Order of Evils responds directly to these questions and dilemmas with one simple and brilliant change of focus. Rather than concentrating on the age-old themes of justice and freedom, Adi Ophir offers a moral theory (...) that emphasizes the existential and political nature of evil. Ophir's main contention is that evil is neither a diabolical element residing in the hearts of men nor a meaningless absence of the good. Rather, it is the socially structured order of "superfluous evils." Evils, like pain, suffering, loss, and humiliation, are superfluous when they could have been -- but were not -- prevented. Through close analysis of seminal works by modern and postmodern philosophers -- from Rousseau, Kant, Marx, Sartre, and Arendt to Foucault, Levinas, Derrida, and Lyotard -- Ophir forges a new perspective for thinking about what it means to be a moral being: to be moral, he argues, is to care for others, and to be committed to preventing, at all costs, their suffering and distress.A theoretically sophisticated work, The Order of Evils also bears the traces of Ophir's own political and personal experiences as an Israeli philosopher and activist. Two major events in recent Jewish history have profoundly influenced his thinking: the Holocaust and the prolonged Israeli domination of Palestinians in the Occupied Territories. Ophir does not compare the two events. Instead, he introduces a typology of disasters that allows them to be located within the wide spectrum of humanly generated calamities whose specificity and general patterns emerge clearly and distinctly as what they are and are not. (shrink)

This paper describes a practice innovation: the addition of formal weekly discussions of patients with prolonged PICU stay to reduce healthcare providers’ moral distress and decrease length of stay for patients with life-threatening illnesses. We evaluated the innovation using a pre/post intervention design measuring provider moral distress and comparing patient outcomes using retrospective historical controls. Physicians and nurses on staff in our pediatric intensive care unit in a quaternary care children's hospital participated in the evaluation. There were 60 patients in (...) the interventional group and 66 patients in the historical control group. We evaluated the impact of weekly meetings to establish goals of care for patients with longer than 10 days length of stay in the ICU for a year. Moral distress was measured intermittently and reported moral distress thermometer scores fluctuated. "Clinical situations" represented the most frequent contributing factor to moral distress. Post intervention, overall moral distress scores, measured on the moral distress scale revised, were lower for respondents in all categories, and on three specific items. Patient outcomes before and after PEACE intervention showed a statistically significant decrease in PRISM indexed LOS, a statistically significant increase in both code status changes DNR, and in-hospital death, with no change in patient 30 or 365 day mortality. The addition of a clinical ethicist and senior intensivist to weekly inter-professional team meetings facilitated difficult conversations regarding realistic goals of care. The study demonstrated that the PEACE intervention had a positive impact on some factors that contribute to moral distress and can shorten PICU length of stay for some patients. (shrink)

Our objective in this paper is twofold: first, we intend to address the tenability of the enactivist middle way between realism and idealism, as it is proposed in The Embodied Mind. We do so by taking the enactivist conception of bringing forth a world literally in three conceptual levels: enaction, niche construction and social construction. Based on this proposal, we claim that enactivism is compatible with the idea of an independent reality without committing to the claim that organisms have cognitive (...) access to a world composed of properties specified prior to any cognitive activity. Our second goal is to show that our literal interpretation of bringing forth a world not only sustains the legitimacy of the middle way, but it also allows us to revive the conception of evolution as natural drift—which is perhaps the least examined aspect of the original enactivist theory and is central to the understanding of cognition in an enactive way. Natural drift focuses on how structural couplings between organism and environment trigger viable pathways of maintenance and reproduction, instead of selecting the most adapted trait to a pregiven environment. Thus, although enactivists typically do not explore the consequences of their views regarding evolutionary dynamics, we show how natural drift provides a suitable starting point. (shrink)

Oftentimes, reality seems to us a chaos that we try to control with our theories. This article starts from the antithetic standpoint, inspired by Antonio Rosmini’s works: reality is intelligible, and originates our thinking. From this perspective, any research that tries to reach the truth is determined by the real, not the contrary. Moreover, interdisciplinarity, far from being a solipsistic enterprise, aims at achieving truth and guaranteeing scientific advancement. Here, we analyze the distinctive character of Rosminian encyclopedism and his principles (...) for preventing human errors. We then clarify why it is impossible to achieve perfection, and why such an impossibility is not problematic for the interdisciplinary dialogue. (shrink)

The general question to be considered in this paper points to the nature of the world described by chemistry: what is macro-chemical ontology like? In particular, we want to identify the ontological categories that underlie chemical discourse and chemical practice. This is not an easy task, because modern Western metaphysics was strongly modeled by theoretical physics. For this reason, we attempt to answer our question by contrasting macro-chemical ontology with the mainstream ontology of physics and of traditional metaphysics. In particular, (...) we introduce the distinction between stuff-ontology, proper of chemistry, and individual-ontology, proper of physics. These two ontologies differ from each other in the basic categories of their own structures. On this basis, we characterize individual-ontology in such a way that the features of stuff-ontology will arise by contrast with it. (shrink)

Although the literature on corporate social responsibility has discussed the scope and meaning of CSR extensively, confusion still exists regarding how to define the concept. One controversial issue deals with the changing legal status of CSR. Based on a review of CSR definitions and meta-studies on CSR definitions, we find that the majority of definitions leans toward voluntary CSR. However, some recent regulatory amendments toward mandatory CSR have called into question the established idea of CSR as merely a managerial tool (...) of self-regulation. In this paper, we juxtapose the evolution of CSR in India against the scholarly literature discussing voluntary-versus-mandatory CSR to understand the recent shift toward a new conceptualization of CSR as a form of co-regulation that includes elements of both voluntary and mandatory regulation. The Indian Companies Act 2013 is a remarkable example in that it replaced an older version from 1956, taking a bold step toward the integration of voluntary and mandatory aspects in the application of CSR. We present practical implications of the Indian case for businesses and discuss implications for CSR theory development; we particularly consider the evolution of the business and society relationship from a voluntary soft law approach to CSR to an increasingly hard law approach and transitory hybrid forms in-between like soft–hard law and hard–soft law. (shrink)

This study examines the evolving role of governments in cultural policy implementation in France, the United Kingdom, and the United States before, during, and after the COVID-19 crisis. The findings reveal distinct cultural policy frameworks before the pandemic, influenced by the unique path dependency of each country. However, in response to the crisis, these countries have converged, experiencing increased government intervention to address national challenges. Notably, the United States, contrary to past efforts, has augmented support for the arts, particularly through (...) the National Endowment for the Arts. The research aims to offer comparative insights into cultural policy during national crises, offering practical lessons for countries facing similar institutional and circumstantial conditions. (shrink)

La investigación propuesta indagó las relaciones que existen entre el derecho a la memoria y el derecho a la ciudad. Para ello se analizaron desde una teoría crítica de los derechos humanos y teniendo como punto de contacto entre ambos derechos las inscripciones espaciales que materializan la memoria colectiva en la ciudad de Madrid. Es así que se buscó comprobar, desde una dimensión jurídica basada en un enfoque de derechos y con perspectiva espacial, si aquellos lugares que materializan y garantizan (...) la memoria pueden a su vez garantizar el acceso al derecho a la ciudad en virtud de que colaboran en la creación de una ciudad más democrática. La metodología empleada consistió en un análisis crítico de textos, relevamiento y estudio exhaustivo de las normas y estándares nacionales e internacionales, políticas públicas locales, observación y registro de los lugares y, por último, una entrevista en profundidad mediante la técnica de muestra de caso sumamente importante para el problema analizado. (shrink)

The goals of the present study were to test whether (and which) basic numerical abilities can be improved with training and whether training effects transfer to improvement in children’s math achievement. The literature is mixed with evidence that does or does not substantiate the efficacy of training basic numerical ability. In the present study, we developed a child-friendly software named ‘123 Bakery’ which includes four training modules; non-symbolic numerosity comparison, non-symbolic numerosity estimation, approximate arithmetic and symbol-to-numerosity mapping. Fifty-six first graders (...) were randomly assigned to either the training or control group. The training group participated in 6 weeks of training (5 times a week, 30 minutes per day). All participants underwent pre- and post- training assessment of their basic numerical processing ability (including numerosity discrimination acuity, symbolic/non-symbolic magnitude estimation, approximate arithmetic, symbol-to-numerosity mapping), overall math achievement and intelligence, 6 weeks apart. The acuity for numerosity discrimination (approximate number sense acuity; ANS acuity) significantly improved after training, but this training effect did not transfer to improvement in symbolic, exact calculation, or any other math ability. We conclude that basic numerical cognition training leads to improvement in ANS acuity, but whether this effect transfers to symbolic math ability remains to be further tested. (shrink)

Considering Rosmini’s political works in comparison with his metaphysical and anthropological essays, and starting from Rosmini's project of a code of law that, in the author’s opinion, can guarantee fundamental human rights, this article discusses the concept of justice between citizens and outsiders. Its first part is an analysis of Rosmini’s juridical fundaments, which takes into account also some objections historically moved against it. Its second part examines some specific cases of conflicts between outsiders and the members of civil society, (...) as considered by the Roveretan philosopher. (shrink)

Moral distress is a well-documented phenomenon for health care providers (HCPs). Exploring HCPs’ perceptions of participation in moral distress interventions using qualitative and quantitative methods enhances understanding of intervention effectiveness. The purpose of this study was to measure and describe the impact of a two-phased intervention on participants’ moral distress. Using a cross-over design, the project aimed to determine if the intervention would decrease moral distress, enhance moral agency, and improve perceptions about the work environment. We used quantitative instruments and (...) explored participants’ perceptions of the intervention using semi-structured interviews. Participants were from inpatient settings, within three major hospitals of a large, urban healthcare system in the Midwest, United States. Participants included nurses (80.6%) and other clinical care providers. Using generalized linear mixed modeling we assessed the change in each of the outcome variables over time controlling for groups. Interviews were audiotaped and professionally transcribed. The written narratives were coded into themes. The change in scores on study instruments trended in the desired direction however did not meet statistical significance. Qualitative interviews revealed that intervention effectiveness was derived from a combination of learning benefits, psychological benefits, and building community that promoted moral agency. Findings demonstrate a clear link between moral distress and moral agency and suggest that Facilitated Ethics Conversations can enhance the work environment. Findings provide insight for developing evidenced-based approaches to address moral distress of hospital nurses. (shrink)

Many published instruments for assessing adolescent adjustment can be implemented in the school context. However, most of them fail to include a comprehensive and positive theoretical perspective of adolescent development and, even when they do, priority is often given to the clinical perspective, or problems with ecological validity and cost-effectiveness emerge. The Magallanes Adaptation Scale is a 90-item Likert-instrument designed for Spanish-speaking adolescents in order to screen several adjustment areas from a holistic and positive perspective of development. Although some evidence (...) of its psychometric robustness has been tested, no confirmatory analysis of its structure has been published. This paper analyzes the items and the factor structure (exploratory factor analysis and confirmatory factor analysis, using the split-half method) of the scales. Participants were 948 Spanish adolescents (49.84% girls) aged between 11 and 17 and stratified sampled. Thirty-six items were removed from the item analysis. The results of the exploratory factor analysis revealed five factors, excluding mother’s adaptation. Several models were tested during the confirmatory factor analyses, with a 24-item second-order four-factor solution being found to have the best adjustment indicators. The short version proposed in this paper can constitute a helpful tool with screening purposes to help school teachers to assess students’ overall development beyond mere academic performance, although further validity research is needed. (shrink)

El objetivo de este texto es investigar sobre los posibles puntos de encuentro entre la psicoterapia existencial, un paradigma psicológico arraigado en las filosofías de la existencia, y el posicionamiento del profesor Marino Pérez Álvarez, quien se define a sí mismo como conductista radical, respecto a su manera de entender la existencia humana y el modelo más adecuado de psicoterapia. Para ello se proponen seis puntos de encuentro: necesidad de una fundamentación filosófica para la psicología, crítica al cientificismo y al (...) modelo médico, interpretación de los trastornos mentales como problemas de la vida cotidiana, recuperación del paciente como protagonista de la terapia, crítica a la psicología positiva y crítica al dualismo cartesiano. (shrink)

Historians and political theorists have long been interested in how the principle of people’s power was conceptualised during the French Revolution. Traditionally, two diverging accounts emerge, one of national and the other of popular sovereignty, the former associated with moderate monarchist deputies, including the Abbé Sieyes, and the latter with the Jacobins. This paper argues against this binary interpretation of the political thought of the French Revolution, in favour of a third account of people’s power, Sieyes’ idea of pouvoir constituant. (...) Traditionally, constituent power has been viewed as a variation of sovereignty, but I show it to be an independent conceptualisation of people’s power. Sieyes’ political theory led him to criticise and refuse contemporary theories of sovereignty in favour of what he understood as a fully modern account of people’s power. Based on extensive research in the archives, I show how Sieyes opposed the deployment of sovereignty by the revolutionary Assemblies and reco... (shrink)

After the establishment of the independent Slovak Republic, legal and institutional ground rules were set for providing asylum to foreigners present on the territory of the Slovak Republic. The national legislation of the last twenty years was adopted in compliance with international treaties and the European Union instruments covering asylum matters. In the field of asylum policy, the Slovak Republic complies with its traditional pillars and supports new forms of protection following the new challenges faced by the international community. The (...) currently valid Asylum Act regulates the international protection of aliens in the Slovak Republic, by defining the conditions and procedures related to granting asylum and provision of subsidiary protection and temporary shelter. The Asylum Act also covers the rights and obligations of different categories of persons, stay in asylum facilities and, partially, the integration of persons that are granted asylum. This article describes and analyses the development of the Slovak asylum legal framework and the concept of asylum policy. Furthermore, it looks at different protection statuses granted to foreigners and finally deals with the refugee migration trends in the Slovak Republic. (shrink)

Os artigos que compõem este dossiê lidam com temas centrais da filosofia da mente e da filosofia da linguagem. Alguns deles abordam temas clássicos e apresentam panoramas em língua portuguesa, de modo que se fazem úteis a jovens leitores. Outros textos apresentam propostas mais ousadas e prometem incitar debate entre filósofos mais experientes. Desse modo, este volume se equilibra ao oferecer conteúdo para diversos públicos. Esta introdução pretende fornecer uma descrição sintética das contribuições deste volume, para que o leitor possa (...) ter uma visão sinóptica do conteúdo apresentado. Em filosofia da mente, há discussões sobre o consciente e o inconsciente, qualia, fisicalismo, alucinações, hipótese da mente estendida, emoções, o problema da lacuna explicativa e reducionismo nas explicações em ciências cognitivas. Em filosofia da linguagem, são tratados temas como a relação entre pensamento e linguagem, normatividade linguística e demonstrativos. Além disso, contamos com textos com abordagens históricas que tratam dos escritos de Wittgenstein acerca da psicologia e da investigação de Antístenes acerca dos nomes. (shrink)